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Tennessee Titans vs Indianapolis Colts prediction

NFL · Sunday, October 18, 2026 · 1:00 PM ET · Lucas Oil Stadium · Fox

Result

Final: Tennessee Titans 26, Indianapolis Colts 20 (Tennessee Titans won). Mel’s pick (Indianapolis Colts win 76% of the time) was wrong. Against the spread, Mel’s lean was wrong.

Mel’s pick

Indianapolis Colts win 76% of the time in Mel’s Playbook’s default simulation of this game, saved before it started.

Projected score

Tennessee Titans 19, Indianapolis Colts 27. 16% of the simulations finished as one-score games.

Mel vs the betting line

Vegas has Indianapolis Colts −6.5. Mel projects Indianapolis Colts by 8.5, so the simulation leans Indianapolis Colts -6.5 against the spread.

The total is 44.5; Mel’s projected 45.7 is right around it.

Recent form

Tennessee Titans (0-5) scored 11.6 and allowed 21.8 points a game over their last 5.

Indianapolis Colts (2-3) scored 24.8 and allowed 27.6 points a game over their last 5.

Based on this season’s stats, injuries, rest, travel and the betting market. Updated Oct 18, 11:20 AM ET.

See the full simulation

Mel’s Playbook Pro shows the range of likely totals and margins, player props and every factor behind the pick, and lets you tune the model (home field, injuries, momentum and more) and re-run the game.

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Every default-model prediction is saved before the game and graded against the final score on our public results page. Simulations are estimates, not guarantees, and this is not betting advice. 21+ where applicable; if gambling is a problem, call 1-800-GAMBLER.