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Indianapolis Colts vs Jacksonville Jaguars prediction

NFL · Sunday, November 1, 2026 · 1:00 PM ET · EverBank Stadium · CBS

Mel’s pick

Jacksonville Jaguars win 63% of the time in Mel’s Playbook’s default simulation of this game.

Projected score

Indianapolis Colts 20, Jacksonville Jaguars 25. 18% of the simulations finished as one-score games.

Mel vs the betting line

Vegas has Jacksonville Jaguars −10. Mel projects Jacksonville Jaguars by 5.5, so the simulation leans Indianapolis Colts +10 against the spread.

The total is 46.5; Mel projects 45 points, a lean to the under.

Recent form

Indianapolis Colts (2-5) scored 20.2 and allowed 21.2 points a game over their last 5.

Jacksonville Jaguars (4-2) scored 24 and allowed 18.8 points a game over their last 5.

Based on this season’s stats, injuries, rest, travel, weather and the betting market. Updated Nov 1, 11:25 AM ET.

See the full simulation

Mel’s Playbook Pro shows the range of likely totals and margins, player props and every factor behind the pick, and lets you tune the model (home field, injuries, momentum and more) and re-run the game.

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Every default-model prediction is saved before the game and graded against the final score on our public results page. Simulations are estimates, not guarantees, and this is not betting advice. 21+ where applicable; if gambling is a problem, call 1-800-GAMBLER.